Salmonella infection: Interplay between the bacteria and host immune system

Abstract

Salmonella infection causes morbidity and mortality throughout the world with the host immune response varying depending on whether the infection is acute and limited, or systemic and chronic. Additionally, Salmonella bacteria have evolved multiple mechanisms to avoid or subvert immunity to its own benefit and often the anatomical location of infection plays a role in both the immune response and bacterial fate. Here, we provide an overview of the interplay between the immune system and Salmonella, while discussing how different host and bacterial factors influence the outcome of infection.

Keywords: B cell; Dendritic cell; Immunomodulation; Infectious disease; Macrophage; Neutrophil; Salmonella; T cell.