Therapeutic Role and Drug Delivery Potential of Neuroinflammation as a Target in Neurodegenerative Disorders

ACS Chem Neurosci. 2017 Aug 16;8(8):1645-1655. doi: 10.1021/acschemneuro.7b00144. Epub 2017 Aug 2.

Abstract

Neuroinflammation, the condition associated with the hyperactivity of immune cells within the CNS (central nervous system), has recently been linked to a host range of neurodegenerative disorders. Targeting neuroinflammation could be of prime importance as recent research highlights the beneficial aspects associated with modulating the inflammatory mediators associated with the CNS. One of the main obstructions in neuroinflammatory treatments is the hindrance posed by the blood-brain barrier for the delivery of drugs. Hence, research has focused on novel modes of transport for drugs to cross the barrier through drug delivery and nanotechnology approaches. In this Review, we highlight the therapeutic advancement made in the field of neurodegenerative disorders by focusing on the effect neuroinflammation treatment has on these conditions.

Keywords: Neuroinflammation; drug delivery; neuroinflammatory drugs.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Infective Agents / administration & dosage
  • Anti-Infective Agents / therapeutic use
  • Blood-Brain Barrier / drug effects
  • Blood-Brain Barrier / immunology
  • Drug Delivery Systems
  • Humans
  • Inflammation / drug therapy*
  • Inflammation / physiopathology
  • Neurodegenerative Diseases / drug therapy*
  • Neurodegenerative Diseases / immunology*
  • Neuroprotective Agents / administration & dosage
  • Neuroprotective Agents / therapeutic use

Substances

  • Anti-Infective Agents
  • Neuroprotective Agents