tRNA Modification: Is Cancer Having a Wobble?

Francesca Rapino; Sylvain Delaunay; Zhaoli Zhou; Alain Chariot; Pierre Close

doi:10.1016/j.trecan.2017.02.004

tRNA Modification: Is Cancer Having a Wobble?

Trends Cancer. 2017 Apr;3(4):249-252. doi: 10.1016/j.trecan.2017.02.004. Epub 2017 Mar 27.

Authors

Francesca Rapino¹, Sylvain Delaunay¹, Zhaoli Zhou¹, Alain Chariot², Pierre Close³

Affiliations

¹ Laboratory of Cancer Signaling, University of Liège, 4000 Liège, Belgium; GIGA-Molecular Biology of Diseases, GIGA-Research, University of Liège, 4000 Liège, Belgium.
² Laboratory of Medical Chemistry, University of Liège, 4000 Liège, Belgium; GIGA-Molecular Biology of Diseases, GIGA-Research, University of Liège, 4000 Liège, Belgium; WELBIO, Avenue Pasteur 6, 1300 Wavre, Belgium.
³ Laboratory of Cancer Signaling, University of Liège, 4000 Liège, Belgium; GIGA-Molecular Biology of Diseases, GIGA-Research, University of Liège, 4000 Liège, Belgium. Electronic address: Pierre.Close@ulg.ac.be.

PMID: 28718436
DOI: 10.1016/j.trecan.2017.02.004

Abstract

Translational control of protein synthesis supports tumor development and progression to metastasis. Wobble tRNA modifications are required during translation elongation and sustain proteome homeostasis. Recent work has highlighted the surprising upregulation of the wobble uridine 34 (U34) tRNA cascade in cancer, which underlies the specific requirement for this pathway in tumor development.

Keywords: cancer; mRNA translation; proteome regulation; wobble tRNA modification.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Neoplasms / genetics*
Protein Biosynthesis / genetics*
RNA, Transfer / genetics*

Substances

RNA, Transfer