Activated ERK: An Emerging Player in miRNA Downregulation

Yiping Qu; Bingyin Shi; Peng Hou

doi:10.1016/j.trecan.2017.01.002

Activated ERK: An Emerging Player in miRNA Downregulation

Trends Cancer. 2017 Mar;3(3):163-165. doi: 10.1016/j.trecan.2017.01.002. Epub 2017 Jan 16.

Authors

Yiping Qu¹, Bingyin Shi², Peng Hou³

Affiliations

¹ Department of Endocrinology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China.
² Department of Endocrinology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China.
³ Department of Endocrinology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China. Electronic address: phou@xjtu.edu.cn.

PMID: 28718429
DOI: 10.1016/j.trecan.2017.01.002

Abstract

To date, the mechanisms underlying global downregulation of miRNAs in cancer remain largely unclear. Recent findings indicate that activated ERK can cause widespread miRNA repression through suppressing the major steps of miRNA biogenesis. Here we discuss how ERK signaling globally downregulates miRNAs and how this contributes to tumorigenesis.

Publication types

Review
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Carcinogenesis / genetics*
Gene Expression Regulation, Neoplastic
Humans
MAP Kinase Signaling System / genetics*
MicroRNAs / genetics*
Neoplasms / genetics*
Neoplasms / pathology

Substances

MicroRNAs