Nickel-Catalyzed Intermolecular Carbosulfonylation of Alkynes via Sulfonyl Radicals

Andrés García-Domínguez; Simona Müller; Cristina Nevado

doi:10.1002/anie.201704862

Nickel-Catalyzed Intermolecular Carbosulfonylation of Alkynes via Sulfonyl Radicals

Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9949-9952. doi: 10.1002/anie.201704862. Epub 2017 Jul 17.

Authors

Andrés García-Domínguez¹, Simona Müller¹, Cristina Nevado¹

Affiliation

¹ Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

PMID: 28715151
DOI: 10.1002/anie.201704862

Abstract

β,β-Disubstituted vinyl sulfones were obtained with complete regio- and stereocontrol in a multicomponent reaction involving alkynes, organoboronic acids, and sulfonyl chlorides in the presence of a nickel catalyst. The reaction proceeds via sulfonyl radicals generated in situ under mild reaction conditions.

Keywords: carbosulfonylation; nickel; stereoselectivity; sulfonyl radicals; vinyl radicals.

Publication types

Research Support, Non-U.S. Gov't