Genetics and the Causes of Ankylosing Spondylitis

Aimee Hanson; Matthew A Brown

doi:10.1016/j.rdc.2017.04.006

Genetics and the Causes of Ankylosing Spondylitis

Rheum Dis Clin North Am. 2017 Aug;43(3):401-414. doi: 10.1016/j.rdc.2017.04.006.

Authors

Aimee Hanson¹, Matthew A Brown²

Affiliations

¹ Translational Research Institute, Princess Alexandra Hospital, University of Queensland Diamantina Institute, Woolloongabba, Brisbane, Queensland, Australia.
² Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology, Woolloongabba, Brisbane, Queensland, Australia. Electronic address: matt.brown@qut.edu.au.

Abstract

Ankylosing spondylitis (AS) is a common inflammatory arthritis in which genetic factors are the primary determinants of disease risk and severity. Substantial progress has been made in identifying genetic pathways involved in the disease, and in translating those discoveries to drug discovery programs. Recently discovered novel disease pathways include those involved in control of DNA methylation, bacterial sensing, and mucosal immunity. Additional pathways are likely to be identified as a higher proportion of the genetic risk of AS is determined.

Keywords: Ankylosing spondylitis; Association; Axial spondyloarthritis; Genetics; Heritability; SNP.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Genetic Pleiotropy
Genetic Predisposition to Disease
HLA-B27 Antigen
Humans
Spondylitis, Ankylosing / genetics*
Spondylitis, Ankylosing / immunology

Substances

HLA-B27 Antigen

Grants and funding

P01 AR052915/AR/NIAMS NIH HHS/United States