Impact of γ-irradiation, ageing and their interactions on multilayer films followed by AComDim

Fanny Gaston; Nathalie Dupuy; Sylvain R A Marque; Magali Barbaroux; Samuel Dorey

doi:10.1016/j.aca.2017.05.021

Impact of γ-irradiation, ageing and their interactions on multilayer films followed by AComDim

Anal Chim Acta. 2017 Aug 15:981:11-23. doi: 10.1016/j.aca.2017.05.021. Epub 2017 Jun 2.

Authors

Fanny Gaston¹, Nathalie Dupuy², Sylvain R A Marque³, Magali Barbaroux⁴, Samuel Dorey⁵

Affiliations

¹ Aix Marseille Univ, CNRS, IRD, Avignon Université, IMBE UMR 7263, 13397, Marseille, France; Aix Marseille Univ, CNRS, ICR, Case 551, 13397 Marseille Cedex 20, France; Sartorius Stedim FMT S.A.S, Z.I. Les Paluds, Avenue de Jouques CS91051, 13781 Aubagne Cedex, France. Electronic address: fanny.gaston@sartorius.com.
² Aix Marseille Univ, CNRS, IRD, Avignon Université, IMBE UMR 7263, 13397, Marseille, France.
³ Aix Marseille Univ, CNRS, ICR, Case 551, 13397 Marseille Cedex 20, France; Vorozhtsov Novosibirsk Institute of Organic Chemistry Office 312, 9 Prospect Academican Laurentiev, 630090 Novosibirsk, Russia.
⁴ Sartorius Stedim FMT S.A.S, Z.I. Les Paluds, Avenue de Jouques CS91051, 13781 Aubagne Cedex, France.
⁵ Sartorius Stedim FMT S.A.S, Z.I. Les Paluds, Avenue de Jouques CS91051, 13781 Aubagne Cedex, France. Electronic address: samuel.dorey@sartorius.com.

PMID: 28693725
DOI: 10.1016/j.aca.2017.05.021

Abstract

To highlight the main factors involved in the degradation of polymers in multilayer films under γ-irradiation, the ANOVA Common Dimensions (AComDim, Analysis of Variance in Common Dimensions) method is applied on spectra recorded with ATR-FTIR (Attenuated Total Reflection-Fourier Transform Infrared). The present study focuses on the stability of γ-irradiated polymers used in single-use plastic bags made of multilayer films for the biopharmaceutical and biotechnological industries. The samples are irradiated at several γ-doses, up to 270 kGy, and compared with a non-irradiated sample used as reference. It shows that the γ-dose, the natural ageing up to six months and the γ-dose × ageing interaction are the most influential factors.

Keywords: AComDim; Ethylene vinyl acetate; FTIR spectra; Polyethylene; γ-irradiation.