The Effects of Time Lag and Cure Rate on the Global Dynamics of HIV-1 Model

Biomed Res Int. 2017:2017:8094947. doi: 10.1155/2017/8094947. Epub 2017 Jun 13.

Abstract

In this research article, a new mathematical model of delayed differential equations is developed which discusses the interaction among CD4 T cells, human immunodeficiency virus (HIV), and recombinant virus with cure rate. The model has two distributed intracellular delays. These delays denote the time needed for the infection of a cell. The dynamics of the model are completely described by the basic reproduction numbers represented by R0, R1, and R2. It is shown that if R0 < 1, then the infection-free equilibrium is locally as well as globally stable. Similarly, it is proved that the recombinant absent equilibrium is locally as well as globally asymptotically stable if 1 < R0 < R1. Finally, numerical simulations are presented to illustrate our theoretical results. Our obtained results show that intracellular delay and cure rate have a positive role in the reduction of infected cells and the increasing of uninfected cells due to which the infection is reduced.

MeSH terms

  • Computer Simulation
  • HIV Infections / therapy*
  • HIV Infections / virology*
  • HIV-1 / physiology*
  • Humans
  • Models, Biological*
  • Numerical Analysis, Computer-Assisted
  • Time Factors