Radiosynthesis of [18F]AV1451 in pharmaceutical conditions and its biological characteristics

Abstract

In this study, we describe the radiosynthesis of [¹⁸F]AV1451 in terms of its pharmaceutical quality and characterise its physical and biological properties. We performed an in vitro serum stability study in fresh human plasma and a plasma protein binding study. The radiochemical yield was 24% (decay corrected), and the product met all regulatory quality requirements. We found that this compound is stable in fresh human plasma and binds tightly to plasma proteins, especially lipoproteins.

Keywords: Neurodegeneration; Plasma protein binding; Radiopharmaceutical drug; TAU protein.