An esterase-activated click and release approach to metal-free CO-prodrugs

Chem Commun (Camb). 2017 Jul 20;53(59):8296-8299. doi: 10.1039/c7cc03832a.

Abstract

One major challenge in the development of CO as a therapeutic agent is its controllable delivery in a pharmaceutically acceptable form. Herein, we describe for the first time a general chemical strategy to esterase-sensitive organic CO-prodrugs.

MeSH terms

  • Animals
  • Carbon Monoxide / chemistry
  • Carbon Monoxide / metabolism*
  • Carbon Monoxide / pharmacology
  • Click Chemistry*
  • Dose-Response Relationship, Drug
  • Esterases / metabolism*
  • Lipopolysaccharides / antagonists & inhibitors
  • Lipopolysaccharides / pharmacology
  • Mice
  • Molecular Structure
  • Prodrugs / chemistry
  • Prodrugs / metabolism*
  • Prodrugs / pharmacology
  • RAW 264.7 Cells
  • Structure-Activity Relationship
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Lipopolysaccharides
  • Prodrugs
  • Tumor Necrosis Factor-alpha
  • Carbon Monoxide
  • Esterases