We should possibly revise our knowledge about risk assessment of splenectomized individuals with β-thalassemia major. Besides their known risk of certain bacterial infection, they might be also in a risk of life-threatening primary cytomegalovirus (CMV) infection and end-, multi-organ disease, in the context of their immunosuppression status. Prompt and appropriate treatment initiation can be life saving.
Keywords: Cytomegalovirus; immunosuppression; pneumonia; splenectomy; β‐thalassemia.