Modeling human disease in rodents by CRISPR/Cas9 genome editing

Marie-Christine Birling; Yann Herault; Guillaume Pavlovic

doi:10.1007/s00335-017-9703-x

Modeling human disease in rodents by CRISPR/Cas9 genome editing

Mamm Genome. 2017 Aug;28(7-8):291-301. doi: 10.1007/s00335-017-9703-x. Epub 2017 Jul 4.

Authors

Marie-Christine Birling¹, Yann Herault^{2

3

4

5

6}, Guillaume Pavlovic²

Affiliations

¹ CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France. birlingm@igbmc.fr.
² CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.
³ Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.
⁴ Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.
⁵ Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France.
⁶ Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.

Abstract

Modeling human disease has proven to be a challenge for the scientific community. For years, generating an animal model was complicated and restricted to very few species. With the rise of CRISPR/Cas9, it is now possible to generate more or less any animal model. In this review, we will show how this technology is and will change our way to obtain relevant disease animal models and how it should impact human health.

Publication types

Review

MeSH terms

Animals
Animals, Genetically Modified
CRISPR-Cas Systems*
Disease Models, Animal
Gene Editing*
Genetic Association Studies / methods*
Genetic Predisposition to Disease*
Genetic Therapy / methods
Genetic Variation
Genomics / methods
Humans
Mice
Models, Biological*
Multifactorial Inheritance
Open Reading Frames
Precision Medicine
RNA, Untranslated
Regulatory Sequences, Ribonucleic Acid

Substances

RNA, Untranslated
Regulatory Sequences, Ribonucleic Acid