Sleep deprivation induces changes in 5-HT actions and 5-HT1A receptor expression in the rat hippocampus

Neurosci Lett. 2017 Aug 10:655:151-155. doi: 10.1016/j.neulet.2017.06.053. Epub 2017 Jun 28.

Abstract

A 12h sleep deprivation enhances the expression of 5-hydroxytryptamine (5-HT) 1A receptors in rat hippocampus that recedes with 48h sleep recovery. The depressant effect of applied 5-HT on the field excitatory postsynaptic potentials recorded in the CA1 area, is also enhanced in hippocampi of SD rats. Following a 24 or 48h sleep recovery, the increase in the 5-HT effect subsided. These results have implications for therapeutics treating clinical depression.

Keywords: 5-HT; CA1; EPSP; Hippocampus; Serotonin; Sleep deprivation.

MeSH terms

  • Animals
  • CA1 Region, Hippocampal / metabolism*
  • Excitatory Postsynaptic Potentials
  • Male
  • Protein Multimerization
  • Rats, Wistar
  • Receptor, Serotonin, 5-HT1A / metabolism*
  • Receptor, Serotonin, 5-HT2A / metabolism
  • Receptors, Metabotropic Glutamate / metabolism
  • Serotonin / metabolism*
  • Serotonin / pharmacology
  • Sleep
  • Sleep Deprivation / metabolism*
  • Synaptic Transmission

Substances

  • Receptor, Serotonin, 5-HT2A
  • Receptors, Metabotropic Glutamate
  • metabotropic glutamate receptor type 1
  • Receptor, Serotonin, 5-HT1A
  • Serotonin