Optical detection and monitoring of pigmented skin lesions

J J Stamnes; G Ryzhikov; M Biryulina; B Hamre; L Zhao; K Stamnes

doi:10.1364/BOE.8.002946

Optical detection and monitoring of pigmented skin lesions

Biomed Opt Express. 2017 May 11;8(6):2946-2964. doi: 10.1364/BOE.8.002946. eCollection 2017 Jun 1.

Authors

J J Stamnes^{1

2}, G Ryzhikov¹, M Biryulina¹, B Hamre^{1

2}, L Zhao¹, K Stamnes^{1

3}

Affiliations

¹ Balter Medical AS, Thormølensgate 55, 5008 Bergen, Norway.
² Department of Physics and Technology, University of Bergen, P.O. Box 7803, 5020 Bergen, Norway.
³ Department of Physics and Engineering Physics, Stevens Institute of Technology, Hoboken, NJ, USA.

Abstract

A method is presented for discriminating between malignant and benign pigmented skin lesions based on multispectral and multi-angle images. It is discussed how to retrieve maps of physiology properties and morphometric parameters from recorded images using a bio-optical model, radiative transfer calculations, and nonlinear inversion, and how to employ automated zooming to extract lesion and surrounding masks. Training and validation of a classification scheme for separation between benign and malignant tissue yielded sensitivity/specificity ranging from 97%/97% for application to a small dataset comprised of lesions not used for training and validation to 99%/93% for application to a larger dataset.

Keywords: (170.1470) Blood or tissue constituent monitoring; (170.3880) Medical and biological imaging; (170.4580) Optical diagnostics for medicine; (170.6935) Tissue characterization.