Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Michalina J Gora; Melissa J Suter; Guillermo J Tearney; Xingde Li

doi:10.1364/BOE.8.002405

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Biomed Opt Express. 2017 Apr 7;8(5):2405-2444. doi: 10.1364/BOE.8.002405. eCollection 2017 May 1.

Authors

Michalina J Gora^{1

2}, Melissa J Suter^{1

3

4}, Guillermo J Tearney^{1

4

5

6}, Xingde Li^{7

8}

Affiliations

¹ Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
² ICube Laboratory, CNRS, Strasbourg University, 1 Place de l'Hopital, Strasbourg 67091, France.
³ Department of Medicine, Division of Pulmonary and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
⁴ Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
⁵ Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
⁶ gtearney@partners.org.
⁷ Department of Biomedical Engineering, Department of Electrical and Computer Engineering, and Department of Oncology, Johns Hopkins University, 720 Rutland Avenue, Traylor 710, Baltimore, MD 21205, USA.
⁸ xingde@jhu.edu.

Abstract

In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forward-viewing probes, along with different scanning mechanisms (proximal-scanning versus distal-scanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic OCT is also discussed.

Keywords: (170.1610) Clinical applications; (170.2150) Endoscopic imaging; (170.4500) Optical coherence tomography; (170.4580) Optical diagnostics for medicine.