Pneumococcal Meningitis Before and After Universal Vaccination With Pneumococcal Conjugate Vaccines 7/13, Impact on Pediatric Hospitalization in Public and Nonpublic Institutions, in Uruguay

Pediatr Infect Dis J. 2017 Oct;36(10):1000-1001. doi: 10.1097/INF.0000000000001671.

Abstract

This is the first study showing the impact of 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis in Latin America; a significant (63.5%) reduction in hospitalization was observed during the first 6 years after starting vaccination. A 90% reduction of pneumococcal conjugate vaccines 7/13 serotypes was observed (P < 0.0001). After vaccination, all strains were penicillin susceptible. Mortality had a reduction of 71%.

MeSH terms

  • Heptavalent Pneumococcal Conjugate Vaccine* / administration & dosage
  • Heptavalent Pneumococcal Conjugate Vaccine* / therapeutic use
  • Hospitalization / statistics & numerical data*
  • Hospitals, Pediatric
  • Humans
  • Immunization / statistics & numerical data*
  • Infant
  • Meningitis, Pneumococcal* / epidemiology
  • Meningitis, Pneumococcal* / prevention & control
  • Pneumococcal Vaccines* / administration & dosage
  • Pneumococcal Vaccines* / therapeutic use
  • Streptococcus pneumoniae
  • Uruguay / epidemiology

Substances

  • 13-valent pneumococcal vaccine
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Pneumococcal Vaccines