A 2,4'-linked tetrahydroxanthone dimer with protein tyrosine phosphatase 1B inhibitory activity from the Okinawan freshwater Aspergillus sp

J Antibiot (Tokyo). 2017 Aug;70(9):967-969. doi: 10.1038/ja.2017.72. Epub 2017 Jun 28.

Authors

Henki Rotinsulu^{1

2}, Hiroyuki Yamazaki¹, Tomohito Miura¹, Satomi Chiba¹, Defny S Wewengkang², Deiske A Sumilat³, Michio Namikoshi¹

Affiliations

¹ Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
² Faculty of Mathematic and Natural Sciences, Sam Ratulangi University, Manado, Indonesia.
³ Faculty of Fisheries and Marine Science, Sam Ratulangi University, Manado, Indonesia.

PMID: 28655930
DOI: 10.1038/ja.2017.72

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aspergillus / metabolism*
Dimerization
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Fresh Water
Japan
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*
Xanthones / chemistry
Xanthones / isolation & purification*
Xanthones / pharmacology

Substances

Enzyme Inhibitors
Xanthones
Protein Tyrosine Phosphatase, Non-Receptor Type 1