Prevalence of factors related to vascular calcifications in patients with chronic kidney disease on dialysis

Medicina (B Aires). 2017;77(3):207-213.

Abstract

The main aim of the study was to determine the prevalence of vascular calcifications in patients with chronic kidney disease on dialysis in our population assessed by X-ray. The secondary objectives were to determine the cardiovascular risk factors associated with the presence of vascular calcifications and to evaluate the complementary use of the echocardiogram in a cross-sectional, observational, multicentric study. We included patients with chronic kidney disease on dialysis, age =18 years with at least 3 months of renal replacement therapy in 8 dialysis centres in Argentina. The degree of vascular calcification was determined using Adragao and Kauppila scores. The presence of valvular calcifications was established through a trans-thoracic doppler echocardiogram. Univariate and multivariate analysis were undertaken, considering the degree of vascular calcification as the dependent variable; 443 adult patients were evaluated at 8 centres across 5 provinces in Argentina. The prevalence of vascular calcifications by the X-rays was 63%, while 73% presented calcifications in hands and pelvis, with an Adragao score > 3, and 60% presented calcifications in the abdominal aorta with a Kauppila score > 4. The prevalence of valvular calcifications: 28%. We have shown a higher rate of vascular calcifications with the use of plain X-rays when compared to the prevalence of valvular calcifications obtained with echocardiograms. In this regard, valvular calcifications were present particularly in those patients with a severe level of radiological vascular calcification.

Keywords: Adragao; Kauppila; chronic kidney disease; dialysis; echocardiography; vascular calcification.

Publication types

  • Observational Study

MeSH terms

  • Argentina / epidemiology
  • Cardiovascular Diseases / diagnostic imaging
  • Cardiovascular Diseases / epidemiology*
  • Cardiovascular Diseases / etiology
  • Cross-Sectional Studies
  • Echocardiography
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Radiography
  • Renal Dialysis* / statistics & numerical data
  • Renal Insufficiency, Chronic / complications*
  • Renal Insufficiency, Chronic / epidemiology
  • Risk Factors
  • Vascular Calcification / classification
  • Vascular Calcification / diagnostic imaging
  • Vascular Calcification / epidemiology*
  • Vascular Calcification / etiology