The role of Krüppel-like factor 14 in the pathogenesis of atherosclerosis

Wei Xie; Liang Li; Xi-Long Zheng; Wei-Dong Yin; Chao-Ke Tang

doi:10.1016/j.atherosclerosis.2017.06.011

The role of Krüppel-like factor 14 in the pathogenesis of atherosclerosis

Atherosclerosis. 2017 Aug:263:352-360. doi: 10.1016/j.atherosclerosis.2017.06.011. Epub 2017 Jun 7.

Authors

Wei Xie¹, Liang Li², Xi-Long Zheng³, Wei-Dong Yin⁴, Chao-Ke Tang⁵

Affiliations

¹ Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Medical Research Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, Hunan, China; Laboratory of Clinical Anatomy, University of South China, Hengyang 421001, Hunan, China.
² Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Medical Research Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, Hunan, China; Department of Pathophysiology, University of South China, Hengyang 421001, Hunan, China.
³ Department of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, The University of Calgary, Health Sciences Center, 3330 Hospital Dr NW, Calgary T2N 4N1, Alberta, Canada.
⁴ Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Medical Research Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, Hunan, China. Electronic address: wdy20042004@126.com.
⁵ Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Medical Research Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, Hunan, China. Electronic address: tangchaoke@qq.com.

PMID: 28641818
DOI: 10.1016/j.atherosclerosis.2017.06.011

Abstract

The Krüppel-like factor (KLF) family, as the SP/XKLF transcription factors, plays important roles in regulating the expression of genes required for the proper execution of important biological and pathological processes. Recent studies have demonstrated that KLF14, a member of the KLF family, participates in the initiation and progression of atherosclerotic cardiovascular disease (CVD). From the molecular function aspect, this review focuses on the impact of KLF14-mediated regulation in major atherosclerosis-related diseases and pathological processes, such as insulin resistance, type 2 diabetes, dyslipidemia, inflammation, obesity, metabolic syndrome, cell proliferation and differentiation. This review was designed to help understand the roles of KLF14 in the pathogenesis of atherosclerosis and define KLF14 as a potential disease biomarker and a novel therapeutic target in CVD.

Keywords: Atherosclerosis; Inflammation; KLF14; Lipid metabolism; Pathogenesis; Type 2 diabetes.

Publication types

Review

MeSH terms

Adipogenesis
Animals
Arteries / metabolism*
Arteries / pathology
Atherosclerosis / epidemiology
Atherosclerosis / genetics
Atherosclerosis / metabolism*
Atherosclerosis / pathology
Cell Differentiation
Cell Proliferation
Humans
Inflammation / epidemiology
Inflammation / metabolism
Inflammation Mediators / metabolism
Insulin Resistance
Kruppel-Like Transcription Factors
Lipid Metabolism
Obesity / epidemiology
Obesity / metabolism
Plaque, Atherosclerotic*
Risk Factors
Signal Transduction
Sp Transcription Factors / genetics
Sp Transcription Factors / metabolism*

Substances

Inflammation Mediators
KLF14 protein, human
Kruppel-Like Transcription Factors
Sp Transcription Factors