Synergism between Naproxen and Rutin in a Mouse Model of Visceral Pain

Drug Dev Res. 2017 Aug;78(5):184-188. doi: 10.1002/ddr.21391. Epub 2017 Jun 22.

Abstract

Preclinical Research The aim of the present study was to evaluate the antinociceptive interaction between naproxen and the glycoside flavonoid, rutin in the acetic acid-induced writhing test in mice. Naproxen (5, 20, 50, and 100 mg/kg p.o.) or rutin (10, 25, 50, and 100mg/kg p.o.) were administered 60 min before the intraperitoneal administration with acetic acid. The dose-response curve of each individual compound and the experimental effective dose 50 (ED50 ) value were obtained to determinate different proportions of the combinations between the two compounds (naproxen-rutin 1:1, 3:1, and 3:1) in the writhing test. The results indicated a synergistic antinociceptive interaction between two drugs with different mechanism of action, naproxen and rutin in all the combinations. Drug Dev Res 78 : 184-188, 2017. © 2017 Wiley Periodicals, Inc.

Keywords: acute visceral pain test; isobolographic analysis; naproxen; rutin; synergism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetic Acid / adverse effects
  • Administration, Oral
  • Analgesics / administration & dosage*
  • Analgesics / pharmacology
  • Animals
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Drug Therapy, Combination
  • Humans
  • Mice
  • Naproxen / administration & dosage*
  • Naproxen / pharmacology
  • Pain Measurement / drug effects
  • Rutin / administration & dosage*
  • Rutin / pharmacology
  • Visceral Pain / chemically induced
  • Visceral Pain / drug therapy*

Substances

  • Analgesics
  • Naproxen
  • Rutin
  • Acetic Acid