Two new diterpenoid lactones isolated from Andrographis paniculata

Chin J Nat Med. 2017 Jun;15(6):458-462. doi: 10.1016/S1875-5364(17)30068-7.

Abstract

In the present study, two new diterpenoid lactones, 3-deoxy-andrographoside (1) and 14-deoxy-15-methoxy-andrographolide (2), were isolated from the aerial parts of Andrographis paniculata. Their structures were elucidated by combination of NMR, MS, and chemical methods. The configurations of 1 and 2 were established based on the analysis of ROESY data and single crystal X-ray diffraction experiment.

Keywords: Acanthaceae; Andrographis paniculata; Diterpenoid lactones.

MeSH terms

  • Andrographis / chemistry*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Lactones / chemistry
  • Lactones / isolation & purification*

Substances

  • Diterpenes
  • Lactones