Base-catalyzed cascade synthesis of 2,3-dihydrofuro[2,3-b]pyridines and 2,3-dihydro-1H-pyrrolo[2,3-b]pyridines from N-propargylic β-enaminones

Xiaobing Yang; Fangzhong Hu; Yang Wang; Chiming Yang; Xiaomao Zou; Jiahui Liu; Qichun Zhang

doi:10.1039/c7cc03308g

Base-catalyzed cascade synthesis of 2,3-dihydrofuro[2,3-b]pyridines and 2,3-dihydro-1H-pyrrolo[2,3-b]pyridines from N-propargylic β-enaminones

Chem Commun (Camb). 2017 Jul 4;53(54):7497-7500. doi: 10.1039/c7cc03308g.

Authors

Xiaobing Yang¹, Fangzhong Hu, Yang Wang, Chiming Yang, Xiaomao Zou, Jiahui Liu, Qichun Zhang

Affiliation

¹ State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China. fzhu@nankai.edu.cn yangchm@nankai.edu.cn.

PMID: 28628175
DOI: 10.1039/c7cc03308g

Abstract

A novel protocol to prepare multi-substituted dihydrofuropyridine and dihydropyrrolopyridine derivatives from KOH-catalyzed reactions between readily available N-propargylic β-enaminones and arylaldehydes or N-sulfonyl imines has been developed in moderate to good yields.