Associations between anhedonia and marijuana use escalation across mid-adolescence

Adam M Leventhal; Junhan Cho; Matthew D Stone; Jessica L Barrington-Trimis; Chih-Ping Chou; Steven Y Sussman; Nathaniel R Riggs; Jennifer B Unger; Janet Audrain-McGovern; David R Strong

doi:10.1111/add.13912

Associations between anhedonia and marijuana use escalation across mid-adolescence

Addiction. 2017 Dec;112(12):2182-2190. doi: 10.1111/add.13912. Epub 2017 Jul 31.

Authors

Affiliations

¹ Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
² Department of Psychology, University of Southern California, Los Angeles, CA, USA.
³ School of Social Work, University of Southern California, Los Angeles, CA, USA.
⁴ Department of Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA.
⁵ Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
⁶ Department of Family Medicine and Public Health, School of Medicine, University of California, San Diego, La Jolla, CA, USA.

Abstract

Background and aims: Anhedonia-a transdiagnostic psychopathological trait indicative of inability to experience pleasure-could lead to and result from adolescent marijuana use, yet this notion has not been tested. This study aimed to estimate the association of: (1) anhedonia at age 14 with rate of change in marijuana use over an 18-month follow-up, and (2) marijuana use at age 14 with rate of change in anhedonia over follow-up. Secondary aims were to test whether gender, baseline marijuana use history and peer marijuana use moderated these associations.

Design: Observational longitudinal cohort repeated-measures design, with baseline (age 14 years), 6-month, 12-month and 18-month follow-up assessments.

Settings: Ten public high schools in Los Angeles, CA, USA, 2013-15.

Participants: Students [n = 3394; 53.5% female, mean (standard deviation) age at baseline = 14.1 (0.42)].

Measurements: Self-report level of anhedonia on the Snaith-Hamilton Pleasure Scale and frequency of marijuana use in the past 30 days.

Findings: Parallel process latent growth curve models adjusting for confounders showed that baseline anhedonia level was associated positively with the rate of increase in marijuana use frequency across follow-ups [β, 95% confidence interval (CI) = 0.115 (0.022, 0.252), P = 0.03]. Baseline marijuana use frequency was not related significantly to the rate of change in anhedonia across follow-ups [β, 95% CI = -0.015 (-0.350, 0.321), P = 0.93]. The association of baseline anhedonia with faster marijuana use escalation was amplified among adolescents with (versus without) friends who used marijuana at baseline [β, 95% CI = 0.179 (0.043, 0.334) versus 0.064 (-0.071, 0.187), interaction P = 0.04], but did not differ by gender or baseline ever marijuana use.

Conclusions: In mid-adolescence, anhedonia is associated with subsequent marijuana use escalation, but marijuana use escalation does not appear to be associated with subsequent anhedonia.

Keywords: Adolescents; anhedonia; longitudinal research; marijuana use; policy; prevention.

Publication types

Observational Study

MeSH terms

Adolescent
Adolescent Behavior / psychology*
Anhedonia / drug effects*
Cohort Studies
Female
Humans
Longitudinal Studies
Los Angeles
Male
Marijuana Use / psychology*
Self Report

Abstract

Publication types

MeSH terms

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