1 Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK. gcb3@cam.ac.uk phs22@cam.ac.uk p.hyslop@utoronto.ca.
2 Department of Clinical Neurosciences, Cambridge Institute for Medical Research, Addenbrookes Hospital, Hills Road, Cambridge CB2 0XY, UK. gcb3@cam.ac.uk phs22@cam.ac.uk p.hyslop@utoronto.ca.
3 Department of Medicine (Neurology), Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto and University Health Network, Toronto, Ontario M5T 2S8, Canada.