Photoacoustic Drug Delivery

Yuqi Zhang; Jicheng Yu; Anna R Kahkoska; Zhen Gu

doi:10.3390/s17061400

Photoacoustic Drug Delivery

Sensors (Basel). 2017 Jun 15;17(6):1400. doi: 10.3390/s17061400.

Authors

Yuqi Zhang^{1

2}, Jicheng Yu^{3

4}, Anna R Kahkoska⁵, Zhen Gu^{6

7

8}

Affiliations

¹ Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA. yzhang96@ncsu.edu.
² Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. yzhang96@ncsu.edu.
³ Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA. jyu17@ncsu.edu.
⁴ Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. jyu17@ncsu.edu.
⁵ Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. anna_kahkoska@med.unc.edu.
⁶ Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA. zgu@email.unc.edu.
⁷ Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. zgu@email.unc.edu.
⁸ Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. zgu@email.unc.edu.

Abstract

Photoacoustic (PA) technology holds great potential in clinical translation as a new non-invasive bioimaging modality. In contrast to conventional optical imaging, PA imaging (PAI) enables higher resolution imaging with deeper imaging depth. Besides applications for diagnosis, PA has also been extended to theranostic applications. The guidance of PAI facilitates remotely controlled drug delivery. This review focuses on the recent development of PAI-mediated drug delivery systems. We provide an overview of the design of different PAI agents for drug delivery. The challenges and further opportunities regarding PA therapy are also discussed.

Keywords: chemotherapy; drug delivery; photoacoustic imaging; photothermal therapy.

Publication types

Review

MeSH terms

Drug Delivery Systems*
Humans
Optical Imaging
Photoacoustic Techniques
Spectrum Analysis
Theranostic Nanomedicine

Grants and funding

UL1 TR001111/TR/NCATS NIH HHS/United States