The association of cannabis use on inpatient psychiatric hospital outcomes

Am J Drug Alcohol Abuse. 2018;44(1):73-84. doi: 10.1080/00952990.2017.1329313. Epub 2017 Jun 14.

Abstract

Background: The associations between cannabis use and psychosis are well documented in numerous studies. There is a need to evaluate the impact of cannabis use on inpatient psychiatric utilization and outcomes.

Objectives: To evaluate the impact of cannabis use on psychiatric hospital outcomes.

Methods: This study was conducted between April 20, 2015 and October 20, 2015. All patients (n = 120) admitted to Denver Health with psychotic symptoms were administered a urine toxicology screening testing for the presence of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH, the active metabolite of cannabis). Patients with positive tests were compared to those with negative tests on several measures, including length of stay, presence or lack of 30-day readmission, Brief Psychotic Rating Scale (BPRS) score, and use of antipsychotics and/or sedatives/anxiolytics.

Results: There were 120 patients. Twenty nine were women and 91 were men. Patients testing positive for THC-COOH had a shorter length of stay compared to patients testing negative for THC-COOH, after adjusting for age, prior psychiatric admissions, history of a psychotic-spectrum disorder, and comorbid additional substance use (p = 0.02). There were no differences in 30-day readmissions, 30-day post-discharge presentation to the Denver Health psychiatric emergency department, BPRS scores, and medication administration.

Conclusion: Patients presenting with psychotic symptoms and cannabis use require shorter inpatient psychiatric hospitalizations. This study is the first to quantify this observation and highlights the need for future clinical decision-making tools that would ideally correlate cannabis use with the degree of potential need for expensive and scarce mental health resources, such as psychiatric hospitalization.

Keywords: cannabis; inpatient psychiatry; marijuana; psychosis.

MeSH terms

  • Adult
  • Anti-Anxiety Agents / therapeutic use
  • Antipsychotic Agents / therapeutic use
  • Dronabinol / analogs & derivatives
  • Dronabinol / urine
  • Female
  • Hospitals, Psychiatric*
  • Humans
  • Inpatients / psychology*
  • Length of Stay / statistics & numerical data*
  • Male
  • Marijuana Use / urine*
  • Middle Aged
  • Patient Readmission / statistics & numerical data
  • Psychotic Disorders / drug therapy
  • Psychotic Disorders / psychology*
  • Psychotic Disorders / urine
  • Treatment Outcome
  • Young Adult

Substances

  • Anti-Anxiety Agents
  • Antipsychotic Agents
  • delta(6)-tetrahydrocannabinol-7-oic acid
  • Dronabinol