Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis

Ana Magalhães; Henrique O Duarte; Celso A Reis

doi:10.1016/j.ccell.2017.05.012

Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis

Cancer Cell. 2017 Jun 12;31(6):733-735. doi: 10.1016/j.ccell.2017.05.012.

Authors

Ana Magalhães¹, Henrique O Duarte², Celso A Reis³

Affiliations

¹ Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135 Porto, Portugal.
² Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135 Porto, Portugal; Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.
³ Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135 Porto, Portugal; Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal; Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal. Electronic address: celsor@ipatimup.pt.

PMID: 28609653
DOI: 10.1016/j.ccell.2017.05.012

Abstract

Glycosylation alterations are involved in several steps of human cancer pathogenesis. In this issue of Cancer Cell, Agrawal et al. identified the glycosyltransferase FUT8 as a previously unrecognized mediator of melanoma metastasis, establishing core fucosylation as a potential therapeutic target for prevention and treatment of metastatic tumors.

Publication types

Comment

MeSH terms

Fucose*
Fucosyltransferases*
Glycosylation
Humans
Melanoma*
Neoplasm Metastasis*
Skin Neoplasms*

Substances

Fucose
Fucosyltransferases