Assessment of nanoparticles' safety: corrected absorbance-based toxicity test

Debora Bonvin; Heinrich Hofmann; Marijana Mionić Ebersold

doi:10.1039/c7an00382j

Assessment of nanoparticles' safety: corrected absorbance-based toxicity test

Analyst. 2017 Jun 26;142(13):2338-2342. doi: 10.1039/c7an00382j.

Authors

Debora Bonvin¹, Heinrich Hofmann, Marijana Mionić Ebersold

Affiliation

¹ Powder Technology Laboratory, Institute of Materials, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

PMID: 28604847
DOI: 10.1039/c7an00382j

Abstract

We developed a method to correct absorbance-based toxicity tests to remove the influence of the deposited dose of nanoparticles. As a model of absorbance-based toxicity tests, we chose the frequently used MTS test. The corrected cell viabilities obtained with the MTS test matched the results of the fluorescence-based PrestoBlue® test.