Synergistic activity of ceftazidime-avibactam and aztreonam against serine and metallo-β-lactamase-producing gram-negative pathogens

Eric Wenzler; Matthew F Deraedt; Amanda T Harrington; Larry H Danizger

doi:10.1016/j.diagmicrobio.2017.05.009

Synergistic activity of ceftazidime-avibactam and aztreonam against serine and metallo-β-lactamase-producing gram-negative pathogens

Diagn Microbiol Infect Dis. 2017 Aug;88(4):352-354. doi: 10.1016/j.diagmicrobio.2017.05.009. Epub 2017 May 18.

Authors

Eric Wenzler¹, Matthew F Deraedt², Amanda T Harrington³, Larry H Danizger⁴

Affiliations

¹ College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: wenzler@uic.edu.
² College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
³ Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA.
⁴ College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA; College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

PMID: 28602518
DOI: 10.1016/j.diagmicrobio.2017.05.009

Abstract

This study assessed the in vitro synergy between ceftazidime, aztreonam, and ceftazidime-avibactam against serine and metallo-β-lactamase (MBL)-producing pathogens via the Etest MIC:MIC ratio and Agar-Etest synergy methods. The combination of aztreonam and ceftazidime-avibactam was synergistic against all Enterobacteriaceae. None of the tested combinations were consistently synergistic against IMP-producing P. aeruginosa.

Keywords: Avibactam; Aztreonam; Carbapenemase; Ceftazidime; Etest; Synergy; beta-Lactamase.

MeSH terms

Anti-Bacterial Agents / therapeutic use
Azabicyclo Compounds / therapeutic use*
Aztreonam / therapeutic use*
Ceftazidime / therapeutic use*
Drug Combinations
Drug Synergism
Enterobacteriaceae / drug effects*
Enterobacteriaceae / metabolism
Gram-Negative Bacterial Infections / drug therapy*
Gram-Negative Bacterial Infections / microbiology
Humans
Pseudomonas aeruginosa / drug effects*
Pseudomonas aeruginosa / metabolism
Serine / metabolism*
beta-Lactamases / metabolism*

Substances

Anti-Bacterial Agents
Azabicyclo Compounds
Drug Combinations
avibactam, ceftazidime drug combination
Serine
Ceftazidime
beta-Lactamases
Aztreonam