Human DNA (cytosine-5)-methyltransferases: a functional and structural perspective for epigenetic cancer therapy

Biochimie. 2017 Aug:139:137-147. doi: 10.1016/j.biochi.2017.06.003. Epub 2017 Jun 6.

Abstract

Epigenetic modifications modulate chromatin states to regulate gene expression. Among them, DNA methylation and histone modifications play a crucial role in the establishment of the epigenome. In cancer, these epigenetic events may act in concert to repress tumor suppressor genes or promote oncogenic pathways. In the context of cancer initiation and progression, recruitment of DNA (cytosine-5)-methyltransferases to specific genomic regions is mainly mediated by histone epigenetic marks, transcription factors and co-regulators as part of a dynamic process. Herein, we will review these mechanisms and present state-of-the-art of DNA methylation, treatment and development of epigenetic cancer therapies targeting this epigenetic modification.

Keywords: DNA methylation; DNMT inhibitors; Epigenetic therapy; Gene body methylation; Promoter methylation; Protein-protein interaction.

Publication types

  • Review

MeSH terms

  • DNA (Cytosine-5-)-Methyltransferases / antagonists & inhibitors*
  • DNA Methylation / drug effects*
  • Epigenesis, Genetic / drug effects*
  • Gene Expression Regulation, Neoplastic / drug effects*
  • Histone Deacetylase Inhibitors / therapeutic use*
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / enzymology
  • Neoplasms / genetics

Substances

  • Histone Deacetylase Inhibitors
  • DNA (Cytosine-5-)-Methyltransferases