Life-threatening sinusoidal obstruction syndrome after high-dose chemotherapy linked to compound heterozygous mutations in ABCB11

Pediatr Blood Cancer. 2017 Dec;64(12). doi: 10.1002/pbc.26666. Epub 2017 Jun 9.

Affiliations

¹ Division of Pediatric Hematology/Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.
² Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of Graz, Graz, Austria.
³ Institute of Human Genetics, Medical University of Graz, Graz, Austria.
⁴ Division of General Pediatrics, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.

PMID: 28598581
DOI: 10.1002/pbc.26666

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 11 / metabolism*
Adolescent
Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Hepatic Veno-Occlusive Disease / chemically induced*
Hepatic Veno-Occlusive Disease / genetics
Humans
Male
Mutation

Substances

ABCB11 protein, human
ATP Binding Cassette Transporter, Subfamily B, Member 11