Abstract
We describe the first gram scale preparation of the reagent dichlorotrifluoromethoxyacetic acid. This stable compound is obtained in five steps starting from the cheap diethylene glycol. The reactivity of the sodium salt of this fluorinated acid was also tested and allowed the preparation of new amides.
Keywords:
amides; fluorine; trifluoromethoxy.
MeSH terms
-
Acetates / chemical synthesis*
-
Amides / chemical synthesis*
-
Chemistry Techniques, Synthetic
-
Ethylene Glycols / chemistry
-
Fluorine / chemistry*
-
Indicators and Reagents / chemical synthesis*
-
Kinetics
-
Molecular Structure
-
Phenyl Ethers / chemical synthesis*
Substances
-
Acetates
-
Amides
-
Ethylene Glycols
-
Indicators and Reagents
-
Phenyl Ethers
-
Fluorine
-
diethylene glycol