Design and evaluation of novel topical formulation with olive oil as natural functional active

Pharm Dev Technol. 2018 Oct;23(8):794-805. doi: 10.1080/10837450.2017.1340951. Epub 2017 Jul 3.

Abstract

Currently, the innovative skin research is focused on the development of novel topical formulations loaded with natural functional actives. The health benefits of olive oil are unsurpassed and many others are revealed as research studies allow the understanding of its unlimited properties. Olive oil has a protective toning effect on skin, but it is not transported effectively into its layers. Aiming the development of a cosmetic formulation for skin photoprotection and hydration, we have prepared and characterized macro-sized particles, made of a hydrogel polymer, loaded with olive oil. Alginate beads were uniform in shape, with minimal oil leakage, offering interesting prospects for encapsulation of lipophilic and poorly stable molecules, like olive oil. In vitro photoprotection and in vivo tolerance tests were in favor of this application. Thus, this study suggests that the incorporation of the olive oil-loaded particles into a cream formulation provides strong moisturizing properties and a photoprotective potential, when applied to healthy subjects.

Keywords: Olive oil; efficacy and safety testing; polymers; skin delivery; suncare/UV protection.

MeSH terms

  • Administration, Cutaneous
  • Adult
  • Alginates / chemistry*
  • Antioxidants / administration & dosage*
  • Antioxidants / chemistry
  • Drug Carriers / chemistry
  • Female
  • Glucuronic Acid / chemistry
  • Hexuronic Acids / chemistry
  • Humans
  • Olive Oil / administration & dosage*
  • Olive Oil / chemistry
  • Olive Oil / pharmacology
  • Particle Size
  • Polyphenols / administration & dosage
  • Polyphenols / analysis
  • Polyphenols / pharmacology
  • Protective Agents / administration & dosage*
  • Protective Agents / chemistry
  • Protective Agents / pharmacology
  • Skin / drug effects
  • Skin / metabolism
  • Skin Cream / chemistry*
  • Sunscreening Agents / administration & dosage*
  • Sunscreening Agents / chemistry
  • Sunscreening Agents / pharmacology
  • Young Adult

Substances

  • Alginates
  • Antioxidants
  • Drug Carriers
  • Hexuronic Acids
  • Olive Oil
  • Polyphenols
  • Protective Agents
  • Sunscreening Agents
  • Glucuronic Acid