Furofuran lignans from the Simpson Desert species Eremophila macdonnellii

Yuen P Tan; Andrei I Savchenko; Natasa Broit; Glen M Boyle; Peter G Parsons; Craig M Williams

doi:10.1016/j.fitote.2017.06.004

Furofuran lignans from the Simpson Desert species Eremophila macdonnellii

Fitoterapia. 2018 Apr:126:93-97. doi: 10.1016/j.fitote.2017.06.004. Epub 2017 Jul 15.

Authors

Yuen P Tan¹, Andrei I Savchenko¹, Natasa Broit², Glen M Boyle², Peter G Parsons², Craig M Williams³

Affiliations

¹ School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane 4072, Australia.
² QIMR Berghofer Medical Research Institute, PO Royal Brisbane Hospital, Brisbane, 4029, Queensland, Australia.
³ School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane 4072, Australia. Electronic address: c.williams3@uq.edu.au.

PMID: 28596028
DOI: 10.1016/j.fitote.2017.06.004

Abstract

The Eremophila plant family, which occurs in the arid zones of Australia, have witnessed extensive investigation, mostly inspired by Aboriginal traditional medicine. A wide and varied biological and phytochemical profile has been reported for over 18 individual species of Australian Eremophila, although E. macdonnellii from the Simpson Desert has not yet been investigated. Isolation and elucidation of one new and six known furofuran lignans are reported. The new lignan, epimethoxypiperitol, displayed moderate anti-cancer activity against the breast cancer cell line (MCF-7).

Keywords: Australian Desert; Eremophila; Lignan; Natural product; Plant natural product.

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Australia
Humans
Lignans / chemistry*
Lignans / isolation & purification
Lignans / pharmacology
MCF-7 Cells
Medicine, Traditional
Molecular Structure
Scrophulariaceae / chemistry*

Substances

Antineoplastic Agents, Phytogenic
Lignans
epimethoxypiperitol