Association of the IL6 rs1800796, but not of the IL6 rs1800795, IL6R rs4845617 and rs2228145 polymorphisms with hip fracture in elderly Mexican women

Aging Clin Exp Res. 2018 Apr;30(4):407-410. doi: 10.1007/s40520-017-0779-7. Epub 2017 Jun 7.

Abstract

Background and aims: Polymorphisms in Interleukin-6 (IL6) and its receptor (IL6R) have been associated with bone mineral density. In this work, the G-174C and G-572C polymorphisms in IL6, G-208A, and Asp358Ala in IL6R were analyzed in Mexican women with hip fracture.

Methods: Postmenopausal Mexican women (60 years or over) with hip fragility fracture (77.97 ± 8 years) and without hip fracture (70.5 ± 7.02 years) were genotyped by real-time PCR.

Results: The rs1800796 GG genotype was associated with low risk of fracture (p = 0.05), while GC genotype was associated with high risk of fracture [p = 0.047, OR 2.3 (95% CI 1.013-5.2)]. The AA genotype of the rs2228145 SNP (IL6R) was significantly different [p = 0.033, OR 1.94 (95% CI 1.01-3.75)], but when data were adjusted by age and body mass index, there were no differences (p = 0.9).

Conclusion: Our results suggest that the IL6 rs1800796 SNP is a good marker for hip fracture risk in Mexican women.

Keywords: Hip fracture; IL-6; IL6R; Polymorphisms.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Body Mass Index
  • Bone Density
  • Female
  • Genotype
  • Hip Fractures / etiology
  • Hip Fractures / genetics*
  • Humans
  • Interleukin-6 / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Receptors, Interleukin-6 / genetics*

Substances

  • IL6R protein, human
  • Interleukin-6
  • Receptors, Interleukin-6