No FAD, No CRY: Redox and Circadian Rhythms

Abstract

There is growing evidence of reciprocal interactions between the endogenous circadian clock and subcellular redox pathways. Recently, researchers at the University of California unearthed another possible link between redox metabolism and the mammalian circadian clock: the redox cofactor FAD stabilises the clock protein cryptochrome (CRY), modifying rhythmic clock gene expression.

Keywords: circadian; cryptochrome; flavin adenine dinucleotide (FAD); metabolism; redox; sleep.