Objective: To know the prevalence of hepatitis B virus (HBV) among women in child-bearing age in Shandong Province, China, providing references to the improvement of HBV control strategy. Methods: The participants were randomly selected by two-stage sampling method from 12 counties which were representative for the whole province. Firstly two townships were selected from each county by probability proportional to size sampling (PPS) method. Then participants aged 1-4 years, 5-14 years, 15-29 years and 30-59 years were selected by stratified random sampling method. The women in child-bearing age (20-49 years) were involved in this study. Questionnaire survey and 5 ml blood collection were conducted among all participants. Blood samples were detected for hepatitis B surface antigen (HBsAg), antibody against HBsAg (anti-HBs) and antibody against hepatitis B core antigen (anti-HBc). Those who were positive for HBsAg were further detected for hepatitis e antigen (HBeAg), antibody against HBeAg (anti-HBe) and the load of HBV DNA. The basic information of the participants including age, gender, occupation, nationality and residence place were collected. The prevalence of HBV infection indicators after weight adjustment were calculated and compared between participants with different demographic characteristics. Results: A total of 1 151 women in child-bearing age were involved in this study. Twenty-seven participants were positive for HBsAg and the prevalence rate was 2.10% (95% CI: 0.97%-3.23%). Five participants were positive for both HBsAg and HBeAg and the prevalence rate was 0.36% (95% CI: 0-0.84%). There were 567 and 291 participants who were positive for anti-HBs and anti-HBc respectively and the corresponding prevalence rates were 47.72% (95%CI: 41.68%-53.75%) and 24.40% (95% CI: 18.50%-30.30%). The number of participants susceptible for HBV was 527 and the percentage of HBV susceptible women was 47.55% (95% CI: 41.63%-53.47%). Conclusion: HBV infection among women in child-bearing age has attained very low level in Shandong Province, China. However, the high proportion of women in child-bearing age were still susceptible for HBV and hepatitis B immunization should be improved among them.
目的： 分析山东省育龄期妇女（20~49岁）乙型肝炎流行现状。 方法： 2014年10月，按照横断面研究原则，在山东省12个县（市、区）采用两阶段分层随机抽样方法，选取1~59岁常住人口作为调查对象。首先采用概率比例规模抽样法在每个调查县（市、区）抽取2个村，然后对调查村常住人口进行摸底调查，按照分层随机抽样方法分别确定1~4、5~14、15~29和30~59岁调查对象，将其中育龄期妇女纳入本研究分析，共1 151名。对所有调查对象进行问卷调查并采集静脉血5 ml，检测HBsAg、抗-HBs和抗-HBc；HBsAg阳性者再检测HBeAg、抗-HBe和HBV DNA载量。问卷调查的内容包括：性别、出生日期、民族、职业、居住地等基本信息。采用抽样权重进行复杂抽样的HBV感染指标阳性率点值估计；采用泰勒级数线性法估计HBV感染指标阳性率的方差，然后构建估计值的95%CI。 结果： 1 151名调查对象中，HBsAg阳性者为27例，阳性率为2.10%（95%CI：0.97%~3.23%）；HBsAg、HBeAg双阳性者为5例，阳性率为0.36%（95%CI：0~0.84%）；抗-HBs阳性者为567例，阳性率为47.72%（95%CI：41.68%~53.75%）；抗-HBc阳性者为291例，阳性率为24.40%（95%CI：18.50%~30.30%）。HBV易感人群为527名，易感率为47.55%（95%CI：41.63%~53.47%）。 结论： 山东省育龄期妇女HBV感染处于较低水平，但约50%人群处于HBV易感状态，应加强易感者乙型肝炎疫苗的接种工作。.
Keywords: Epidemiologic studies; Hepatitis B; Hepatitis B vaccine; Women in child-bearing age.