Swiprosin-1: Its Expression and Diverse Biological Functions

J Cell Biochem. 2018 Jan;119(1):150-156. doi: 10.1002/jcb.26199. Epub 2017 Jun 30.

Abstract

Swiprosin-1/EFhd2 is a Ca2+ binding adapter protein involved in the various cellular functions. Swiprosin-1 is significantly upregulated in a number of pathological conditions of inflammation, neurodegeneration, and cancer. Swiprosin-1 associated with actin and its expression level amplifies the production of proinflammatory mediators and modulates the activation of transcription factor during immune cells activation. This review aims at providing an overview of the expression and function of swiprosin-1/EFhd2 in various pathophysiological conditions. We also discussed the key role of swiprosin-1 in immune cell activation, cell migration, apoptosis, humoral immunity, cancer invasion and metastasis, neuronal transport, and major signaling cascades. J. Cell. Biochem. 119: 150-156, 2018. © 2017 Wiley Periodicals, Inc.

Keywords: IMMUNE CELLS ACTIVATION; PROTEIN KINASE; RECEPTOR SIGNALING; SWIPROSIN-1.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis
  • Axonal Transport
  • Calcium-Binding Proteins / metabolism
  • Calcium-Binding Proteins / physiology*
  • Cell Movement
  • Humans
  • Immune System / immunology
  • Immunity, Humoral
  • NF-kappa B / metabolism
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Signal Transduction

Substances

  • Calcium-Binding Proteins
  • EFHD2 protein, human
  • NF-kappa B