Prenylated flavonoids from Commiphora opobalsamum stem bark

Ali A El-Gamal; Shaza M Al-Massarani; Wael M Abdel-Mageed; Amina El-Shaibany; Hassan M Al-Mahbashi; Omer A Basudan; Farid A Badria; Mansour S Al-Said; Maged S Abdel-Kader

doi:10.1016/j.phytochem.2017.05.014

Prenylated flavonoids from Commiphora opobalsamum stem bark

Phytochemistry. 2017 Sep:141:80-85. doi: 10.1016/j.phytochem.2017.05.014. Epub 2017 Jun 3.

Authors

Ali A El-Gamal¹, Shaza M Al-Massarani², Wael M Abdel-Mageed³, Amina El-Shaibany⁴, Hassan M Al-Mahbashi⁵, Omer A Basudan², Farid A Badria⁶, Mansour S Al-Said², Maged S Abdel-Kader⁷

Affiliations

¹ Department of Pharmacognosy, King Saud University, College of Pharmacy, P.O. Box 2457, Riyadh, 11451, Saudi Arabia; Department of Pharmacognosy, Mansoura University, Faculty of Pharmacy, 35516, El-Mansoura, Egypt. Electronic address: aelgamal00@yahoo.com.
² Department of Pharmacognosy, King Saud University, College of Pharmacy, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
³ Department of Pharmacognosy, King Saud University, College of Pharmacy, P.O. Box 2457, Riyadh, 11451, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt. Electronic address: waelcognosy@yahoo.com.
⁴ Department of Pharmacognosy, College of Pharmacy, P.O. Box 33039, Sana'a University, Sana'a, Yemen.
⁵ Department of Forensic Medicine and Clinical Toxicology, College of Medicine, Sana'a University, Sana'a, Yemen.
⁶ Department of Pharmacognosy, Mansoura University, Faculty of Pharmacy, 35516, El-Mansoura, Egypt.
⁷ Department of Pharmacognosy, Sattam Bin Abdulaziz University, College of Pharmacy, 11942, Al-kharj, Saudi Arabia.

PMID: 28582635
DOI: 10.1016/j.phytochem.2017.05.014

Abstract

A phytochemical study on the stem bark of Commiphora opobalsamum looking for cytotoxic compounds afforded eleven flavonoids, including six previously undescribed prenylated congeners, comophorin A-E, and comophoroside A. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Isolated compounds were biologically evaluated using in vitro cytotoxicity MTT-based assay against two cancer cell lines; namely human hepato-cellular carcinoma (HepG-2) and human breast adenocarcinoma (MCF-7). Comophoroside A revealed to retain the strongest cytotoxic activity against MCF-7 and HepG-2 cell lines with IC₅₀ values of 8 and 12 μg/mL, respectively.

Keywords: Burseraceae; Commiphora opobalsamum; Cytotoxic activity; Flavonoids; Prenylated flavonoids.

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Commiphora / chemistry*
Drug Screening Assays, Antitumor
Flavonoids / chemistry*
Flavonoids / isolation & purification
Hep G2 Cells
Humans
MCF-7 Cells
Molecular Structure
Plant Bark / chemistry*
Prenylation

Substances

Antineoplastic Agents, Phytogenic
Flavonoids