Rare GCH1 heterozygous variants contributing to Parkinson's disease

Qian Xu; Kai Li; Qiying Sun; Dongxue Ding; Yuwen Zhao; Nannan Yang; Yang Luo; Zhenhua Liu; Yuan Zhang; Chunrong Wang; Kun Xia; Xinxiang Yan; Hong Jiang; Lu Shen; Beisha Tang; Jifeng Guo

doi:10.1093/brain/awx110

Rare GCH1 heterozygous variants contributing to Parkinson's disease

Brain. 2017 Jul 1;140(7):e41. doi: 10.1093/brain/awx110.

Authors

Qian Xu^{1

2}, Kai Li¹, Qiying Sun^{1

2}, Dongxue Ding¹, Yuwen Zhao¹, Nannan Yang¹, Yang Luo¹, Zhenhua Liu¹, Yuan Zhang¹, Chunrong Wang¹, Kun Xia², Xinxiang Yan¹, Hong Jiang^{1

2

3

4}, Lu Shen^{1

2

3

4}, Beisha Tang^{1

2

3

4

5

6

7}, Jifeng Guo^{1

2

3

4}

Affiliations

¹ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
² National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, Hunan, P.R. China.
³ State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, P.R. China.
⁴ Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, P.R. China.
⁵ Parkinson's Disease Center of Beijing Institute for Brain Disorders, Beijing, P.R. China.
⁶ Collaborative Innovation Center for Brain Science, Shanghai, P.R. China.
⁷ Collaborative Innovation Center for Genetics and Development, Shanghai, P.R. China.

PMID: 28582483
DOI: 10.1093/brain/awx110

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Case-Control Studies
China / epidemiology
Cohort Studies
Female
GTP Cyclohydrolase / genetics*
Genetic Predisposition to Disease / epidemiology
Genetic Predisposition to Disease / genetics*
Genetic Variation / genetics*
Humans
Male
Middle Aged
Parkinson Disease / diagnosis
Parkinson Disease / epidemiology
Parkinson Disease / genetics*

Substances

GTP Cyclohydrolase