Mucosal bacterial dissemination in a rhesus macaque model of experimental brucellosis

J Med Primatol. 2018 Feb;47(1):75-77. doi: 10.1111/jmp.12282. Epub 2017 Jun 2.

Abstract

Animals were experimentally infected with Brucella melitensis via aerosol. B. melitensis was cultured from the saliva and vaginal vault of infected animals, corresponding to bacterial dissemination in other target tissues. This is the first report of bacterial dissemination to these mucosal surfaces in a non-human primate model of brucellosis.

Keywords: Brucella melitensis; aerosol exposure; mucosal dissemination; rhesus macaque.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aerosols / administration & dosage
  • Animals
  • Brucella melitensis / physiology*
  • Brucellosis / etiology
  • Brucellosis / microbiology*
  • Female
  • Macaca mulatta
  • Male
  • Mucous Membrane / microbiology*
  • Saliva / microbiology*
  • Vagina / microbiology*

Substances

  • Aerosols