KDM5A demethylase: Erasing histone modifications to promote repair of DNA breaks

J Cell Biol. 2017 Jul 3;216(7):1871-1873. doi: 10.1083/jcb.201705005. Epub 2017 Jun 1.

Abstract

Repairing DNA breaks within the complexity of the cell chromatin is challenging. In this issue, Gong et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201611135) identify the histone demethylase KDM5A as a critical editor of the cells' "histone code" that is required to recruit DNA repair complexes to DNA breaks.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Chromatin*
  • DNA Breaks
  • DNA Repair
  • Histone Code*
  • Histones / genetics

Substances

  • Chromatin
  • Histones