Objective: To investigate the clinical and pathological features and prognosis of white lesion of vocal cord. Methods: One hundred and fifty-four cases of white lesion of vocal cord from January 2009 to February 2016 were retrospectively analysed. All the patients had undergone the resection of white lesion of vocal cord resection through retaining laryngoscope under general anesthesia with the specimens pathologically examined. Results: There were 148 males and 6 females in this study. The ages ranged from 36 to 83 years, and the median age was 54.5.There were 103(66.88%) long-term smokers, and 64(41.56%) long-term drinkers. Postoperative pathology showed that chronic mucosal inflammation in 19 cases (12.34%), squamous epithelial hyperplasia in 56 cases(36.36%), mild dysplasia in 25 cases(16.23%), moderate dysplasia in 34 cases(22.08%), severe dysplasia in 12 cases(7.79%), carcinoma in situ in 6 cases(3.90%), and invasive carcinoma in 2 cases(1.30%). The recurrence rate and canceration rate of chronic mucosal inflammation were 0. The recurrence rate of squamous epithelial hyperplasia was 10.71%, the canceration rate was 0.The recurrence rate of mild dysplasia was 8.00%, the canceration rate was 0. The recurrence rate of moderate dysplasia was 20.59%, the canceration rate was 8.82%. The recurrence rate of severe dysplasia was 25.00%, the canceration rate was 16.67%. Conclusions: White lesion of vocal cord is a predominantly male disease. Long-term smokering and drinking are one of common causes. The final diagnosis of white lesion of vocal cord relies on the pathology. Closed observation is necessary for theses dysplasia cases. The majority of which are benign, the operation effect is good.
目的： 研究声带黏膜白色病变患者的临床表现、病理特征及其预后。 方法： 回顾性分析2009年1月至2016年2月154例声带黏膜白色病变患者的临床及病理学资料，患者均在全身麻醉下行显微支撑喉镜下声带黏膜白色病变切除术，术后切除的病变组织送病理检查。 结果： 154例声带黏膜白色病变患者中，男148例，女6例；年龄36～83岁，中位年龄54.5岁。长期吸烟者103例(66.88%)，长期饮酒者64例(41.56%)。病理检查显示：黏膜慢性炎性反应19例(12.34%)，鳞状上皮增生56例(36.36%)，黏膜轻度异形增生25例(16.23%)，中度异形增生34例(22.08%)，重度异形增生12例(7.79%)，原位癌6例(3.90%)，浸润癌2例(1.30%)。黏膜慢性炎性反应复发率及癌变率均为0；鳞状上皮增生复发率10.71%，癌变率为0；黏膜轻度异形增生术后复发率为8.00%，癌变率为0；中度异形增生术后复发率20.59%，癌变率为8.82%；重度异形增生术后复发率25.00%，癌变率为16.67%。 结论： 声带黏膜白色病变的患者以男性居多，长期吸烟、饮酒可能是其主要病因之一。病理结果作为诊断病变性质的依据，病变以良性居多，对于病理检查提示有异形增生的患者需密切随诊观察。手术治疗效果较好。.
Keywords: Lasers, gas; Leukoplakia; Pathology, clinical; Vocal cords.