MitomiRs Keep the Heart Beating

Adv Exp Med Biol. 2017:982:431-450. doi: 10.1007/978-3-319-55330-6_23.

Abstract

In this chapter, we focus on the microRNAs (miRNAs or miRs) that have been found in the mitochondrial compartment, and target either mitochondrial or nuclear encoded genes present in mitochondria, leading to an alteration of mitochondrial function. We term this subset of miRNAs as "MitomiRs".

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / genetics
  • Cardiovascular Diseases / metabolism*
  • Cardiovascular Diseases / pathology
  • Cardiovascular Diseases / physiopathology
  • Gene Expression Regulation
  • Heart Rate*
  • Humans
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Mitochondria, Heart / metabolism*
  • Mitochondria, Heart / pathology
  • Mitochondrial Dynamics
  • Myocardial Contraction*
  • Myocytes, Cardiac / metabolism*
  • Myocytes, Cardiac / pathology
  • RNA / genetics
  • RNA / metabolism*
  • RNA, Mitochondrial
  • Signal Transduction*

Substances

  • MicroRNAs
  • RNA, Mitochondrial
  • RNA