Statins Determination: A Review of Electrochemical Techniques

Crit Rev Anal Chem. 2017 Nov 2;47(6):474-489. doi: 10.1080/10408347.2017.1332973. Epub 2017 May 26.

Abstract

The use of electroanalytical techniques for the determination of statins (Atorvastatin, Fluvastatin, Lovastatin, Pitavastatin, Pravastatin, Rosuvastatin and Simvastatin) is reviewed covering the period from 1997 to 2016. Among all of the published electrochemical methods, voltammetry and polarography are the most popular techniques for the determination of statins, and both are used for the analysis of pharmaceutical dosage forms and biological samples. The determination of statins by a potentiometric method using ion-selective electrodes is reported in only few papers. Сoulometry and conductometry have been not used for the determination of statins till date. Current trends in developing new electrochemical methods for the analysis of statins are discussed.

Keywords: Biological media; drug analysis; potentiometry; statin; voltammetry.

Publication types

  • Review

MeSH terms

  • Electric Conductivity
  • Electrochemical Techniques*
  • Electrodes
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / analysis*

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors