In this Perspective, we provide an overview of the pressure-induced effects on hybrid organic-inorganic perovskite for photovoltaics applications. It is shown that a fine-tuning of the most relevant photovoltaic properties, including band gap and carrier lifetime, is indeed possible by applying pressure over a rather small range and that such phenomena closely correlate with pressure-induced structural changes. High-pressure research can be used to search for new materials since the high-pressure structural configuration can be used as a model for tailoring ambient pressure compounds under proper chemical substitution, and the band gap tuning and enhancement of carrier lifetime with applied pressures can be a guide to design new hybrid perovskites with desired optical properties as a function of structural parameters.