The role of dyslipidemia in diabetic retinopathy

Sandra S Hammer; Julia V Busik

doi:10.1016/j.visres.2017.04.010

The role of dyslipidemia in diabetic retinopathy

Vision Res. 2017 Oct:139:228-236. doi: 10.1016/j.visres.2017.04.010. Epub 2017 May 26.

Authors

Sandra S Hammer¹, Julia V Busik²

Affiliations

¹ Department of Physiology, Michigan State University, East Lansing, MI, United States.
² Department of Physiology, Michigan State University, East Lansing, MI, United States. Electronic address: busik@msu.edu.

Abstract

Diabetic retinopathy (DR) affects over 93million people worldwide and is the number one cause of blindness among working age adults. These indicators coupled with the projected rise of patients diagnosed with diabetes, makes DR a serious and prevalent vision threating disease. Data from recent clinical trials demonstrate that in addition to the well accepted role of hyperglycemia, dyslipidemia is an important, but often overlooked factor in the development of DR. The central aim of this review article is to showcase the critical role of dyslipidemia in DR progression as well as highlight novel therapeutic solutions that take advantage of the vital roles lipid metabolism plays in DR progression.

Keywords: ASM; Bone marrow; Cholesterol metabolism; Diabetic retinopathy; Dyslipidemia; Fatty acids; Inflammation; Liver X receptor; miR-15a.

Publication types

Review

MeSH terms

Diabetic Retinopathy / physiopathology*
Disease Progression
Dyslipidemias / physiopathology*
Humans
Lipid Metabolism

Abstract

Publication types

MeSH terms

Grants and funding