Intracranial Gadolinium Deposition Following Gadodiamide-Enhanced Magnetic Resonance Imaging in Pediatric Patients: A Case-Control Study

Jennifer S McDonald; Robert J McDonald; Mark E Jentoft; Michael A Paolini; David L Murray; David F Kallmes; Laurence J Eckel

doi:10.1001/jamapediatrics.2017.0264

Intracranial Gadolinium Deposition Following Gadodiamide-Enhanced Magnetic Resonance Imaging in Pediatric Patients: A Case-Control Study

JAMA Pediatr. 2017 Jul 1;171(7):705-707. doi: 10.1001/jamapediatrics.2017.0264.

Authors

Jennifer S McDonald¹, Robert J McDonald¹, Mark E Jentoft², Michael A Paolini², David L Murray², David F Kallmes³, Laurence J Eckel¹

Affiliations

¹ Department of Radiology, College of Medicine, Mayo Clinic, Rochester, Minnesota.
² Department of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic, Rochester, Minnesota.
³ Department of Radiology, College of Medicine, Mayo Clinic, Rochester, Minnesota3Department of Neurosurgery, College of Medicine, Mayo Clinic, Rochester, Minnesota.

Abstract

This study determines the extent of deposition in gadolinium-based contrast agent–exposed pediatric population and whether prior observations were related to age-dependent breakdown of the blood blood-brain barrier.

MeSH terms

Adolescent
Brain / metabolism*
Case-Control Studies
Child
Child, Preschool
Contrast Media / adverse effects*
Gadolinium / metabolism*
Gadolinium DTPA / adverse effects*
Humans
Magnetic Resonance Imaging / adverse effects
Retrospective Studies

Substances

Contrast Media
gadodiamide
Gadolinium
Gadolinium DTPA