Abstract
The flavoprotein nitroalkane oxidase catalyzes the oxidation of neutral nitroalkanes to the corresponding aldehydes or ketones, releasing nitrite and transferring electrons to O2 to form H2O2. A combination of solution and structural analyses have provided a detailed understanding of the mechanism of this enzyme.
Keywords:
Flavoprotein; Mechanism; Nitroalkane oxidase; Nitronate monooxygenase; Structure.
Copyright © 2017 Elsevier Inc. All rights reserved.
Publication types
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Review
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Research Support, N.I.H., Extramural
MeSH terms
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Aldehydes / chemistry
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Aldehydes / metabolism
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Catalysis
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Dioxygenases / chemistry*
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Dioxygenases / metabolism
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Electron Transport
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Flavoproteins / chemistry*
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Flavoproteins / metabolism
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Hydrogen Peroxide / chemistry
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Hydrogen Peroxide / metabolism
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Ketones / chemistry
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Ketones / metabolism
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Nitrites / chemistry
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Nitrites / metabolism
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Oxygen / chemistry
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Oxygen / metabolism
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Structure-Activity Relationship
Substances
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Aldehydes
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Flavoproteins
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Ketones
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Nitrites
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Hydrogen Peroxide
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Dioxygenases
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2-nitropropane dioxygenase
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Oxygen