Nitroalkane oxidase: Structure and mechanism

Arch Biochem Biophys. 2017 Oct 15:632:41-46. doi: 10.1016/j.abb.2017.05.012. Epub 2017 May 18.

Abstract

The flavoprotein nitroalkane oxidase catalyzes the oxidation of neutral nitroalkanes to the corresponding aldehydes or ketones, releasing nitrite and transferring electrons to O2 to form H2O2. A combination of solution and structural analyses have provided a detailed understanding of the mechanism of this enzyme.

Keywords: Flavoprotein; Mechanism; Nitroalkane oxidase; Nitronate monooxygenase; Structure.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aldehydes / chemistry
  • Aldehydes / metabolism
  • Catalysis
  • Dioxygenases / chemistry*
  • Dioxygenases / metabolism
  • Electron Transport
  • Flavoproteins / chemistry*
  • Flavoproteins / metabolism
  • Hydrogen Peroxide / chemistry
  • Hydrogen Peroxide / metabolism
  • Ketones / chemistry
  • Ketones / metabolism
  • Nitrites / chemistry
  • Nitrites / metabolism
  • Oxygen / chemistry
  • Oxygen / metabolism
  • Structure-Activity Relationship

Substances

  • Aldehydes
  • Flavoproteins
  • Ketones
  • Nitrites
  • Hydrogen Peroxide
  • Dioxygenases
  • 2-nitropropane dioxygenase
  • Oxygen