Ebolavirus's Foibles

Seiya Yamayoshi; Yoshihiro Kawaoka

doi:10.1016/j.cell.2017.05.008

Ebolavirus's Foibles

Cell. 2017 May 18;169(5):773-775. doi: 10.1016/j.cell.2017.05.008.

Authors

Seiya Yamayoshi¹, Yoshihiro Kawaoka²

Affiliations

¹ Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
² Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA; Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. Electronic address: yoshihiro.kawaoka@wisc.edu.

PMID: 28525748
DOI: 10.1016/j.cell.2017.05.008

Abstract

Ebola virus disease poses a global health threat. Here, two studies by Wec et al. and Zhao et al. identified vulnerability in an internal fusion loop of an ebolavirus glycoprotein. Monoclonal antibodies elicited from immunization and isolated from a human survivor that recognized epitopes in this area neutralized all five ebolaviruses, guiding the development of a pan-ebolavirus immunotherapy.

Publication types

Comment

MeSH terms

Animals
Antibodies, Monoclonal / immunology
Antibodies, Viral / immunology
Ebolavirus / immunology*
Epitopes / immunology
Hemorrhagic Fever, Ebola / immunology*
Humans
Mice
Mice, Inbred BALB C

Substances

Antibodies, Monoclonal
Antibodies, Viral
Epitopes